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Database search
November 2009 release, R14
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This tool is designed to search and download specific data and to analyze datasets contents.
If you have any difficulties in using this tool, or have any questions or comments regarding the web site, you may either
contact us at , or read the help file that provides information on how to search and retrieve data,
and on database annotations and contents, or check the FAQ.
Click on the images to go to search options.
Search options and graphics have been optimized for PC computers using Internet Explorer 5 or
later versions. Using other web browsers may not work properly. With Mac OS X computers, use Safari.
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Search database for data related to SOMATIC MUTATIONS:
Select: tumor type Retrieve: mutation pattern
Display the proportion of mutations grouped by type of base change, effect, codon position or
functional impact in a selected type of tumor(s). (?)
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Select: multiple criteria Retrieve: mutation pattern
Select more than 20 criteria to retrieve the mutation spectrum of a specific dataset. (?)

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Select: multiple criteria Retrieve: mutation prevalence
Search for TP53 mutation prevalence in selected types of tumor and populations. (?)

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Search database for data related to SOMATIC OR GERMLINE MUTATIONS:
Select: mutation Retrieve: tumor spectrum
Display a histogram showing the distribution of tumors associated with the selected germline or somatic mutation(s). (?)
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Select: mutation Retrieve: mutation summary
Check if the selected mutation exist and display a summary of data available for this mutation. (?)
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Select: multiple criteria Retrieve: cell-lines
Search the TP53 gene status of human cancer cell-lines. (?)
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Search OTHER datasets:
Select: mutation Retrieve: biological activities
Display biological activities tested in experimental assays in human or yeast cells. (?)
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Select: multiple criteria Retrieve: structures
Use various tools to retrieve data on structure of mutant p53 proteins (?)

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Search all datasets with SRS
SRS allow for multiple user-defined queries and data retrieval in table or html formats. SRS integration provided by Paolo Romano, IST, Genova, Italy.

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Polymorphisms
Display polymorphic sites with links to specialized databases (?)
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Mouse models
Display mouse models with engineered TP53 (?)
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Protein interactions
Visit Human Protein Reference Database to view p53 protein-protein interactions and post-translational modifications on p53.
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The search application has been created by Lambda-plus
and further developed at IARC.

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