The IARC TP53 Database compiles TP53 gene variations identified in human populations and tumor samples. Data are compiled from the peer-reviewed literature and from generalist databases.

The following datasets are available:

• TP53 somatic mutations in sporadic cancers
• TP53 germline mutation in familial cancers
• Common TP53 polymorphisms identified in human populations
• Functional and structural properties of p53 mutant proteins
• TP53 gene status in human cell-lines
• Mouse-models with engineered TP53

See detailed information on database contents in the user's guide.


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