November 2009:

• The dataset of somatic mutations has been updated with data reported in publications edited in PubMed in 2007 and the dataset of germline mutations has been updated with data reported in publications edited between August 2008 and August 2009. The datasets of functional activities of p53 mutant proteins and of mouse-models have not been updated. This R14 release contains 26597 somatic mutations, 535 germline mutations, functional data on 2314 mutant proteins and TP53 gene status of 1993 cell-lines.
• New annotations have been generated on the predicted impact of mutations on the status of p53 protein isoforms (see details here). These annotations can be retrieved from the 'Mutation Validation' search option.
• Statistics on the prevalence of TP53 germline mutations in selected cohorts has been added here.

 November 2008:

A new reference sequence is used for TP53 gene. This sequence is based on the most recent version of the genome assembly. Its GenBank reference is NC_000017 (7512445..7531642). Sequences of the introns are more complete and acurate than in refseq X54156. The only change in exons is at the polymorphic site in codon 72, where a C is present in the new refseq, while a G was present in refseq X54156. Note that some mutations have been reannotated in light of the new sequence.
The database has been updated with data reported in publications edited in PubMed in 2007. All datasets have been updated except the dataset of somatic mutations. This R13 release contains 24785 somatic mutations, 423 germline mutations, functional data on 2314 mutant proteins and TP53 gene status of 1894 cell-lines.
New annotations on the predicted impact of mutations on splicing have been generated with available algorithms (see details here).
Information on polymorphism frequency has been added in the dataset of polymorphisms.
New annotations were introduced for the description of mutations to comply with HGVS standards.
All missense mutations reported in the IARC TP53 database have been submitted to SwissProt. Links between the two databases are thus now available.

 November 2007:

The database has been updated with data reported in publications edited in PubMed in 2006. This R12 release contains 24810 somatic mutations, 399 germline mutations, functional data on 2314 mutant proteins and TP53 gene status of 1886 cell-lines.
A new dataset on mouse-models with engineered p53 has been added. There are 545 models listed in R12.
In the Function dataset 1, data on endogenous mutants have been added and an "assay design" has been assigned to each experiment to emphasize the quality of the data.
Data on protein stability of some mutants have been added.

 November 2006:

The database has been updated with data reported in publications edited in PubMed in 2005. This R11 release contains 23544 somatic mutations, 376 germline mutations, functional data on 2314 mutant proteins and TP53 gene status of 1569 cell-lines.
The dataset on TP53 gene status in cell-lines has been greetly extended and a search tool has been developed to easily retrieve data.
The list of polymorphisms has been extended and updated with data from SNP databases, and links to other databases providing additional information on population frequency and disease associations have also been included.
A new classification for the transactivation capacity of mutant proteins has been generated from the original data by Kato et al. (2003)
New tools and information have been addded in the "TP53 resources" section, including a viewer of the genomic sequence of TP53 with exon-intron boundaries and highlighted polymorphic sites, and a list of p53 response-elements with their sequence and location.

 November 2005:

Annotations on the functional impact (predicted or observed in experimental assays) of mutations have been added, as well as nucleotide substitution rates for each specific mutation. New interactive scatter plot graphs can be drawn to display this information.
The dataset on the transactivation activities of 2314 missense mutants on 8 p53-target genes generated by Kato et al. (2003) has been integrated in the database and can be downloaded with the mutation dataset.
A mutation validation tool has been implemented to check if a mutation is listed in the database and what is its functional impact.
A summary view of the properties of specific mutations can be obtained from the scatter plot graphs or from the mutation validation tool.
A search option has been added to analyze tumor spectrum associated with specific germline mutations.

 July 2005:

The database has been updated with data reported in publications edited in PubMed in 2004. This R10 release contains 21,587 somatic mutations, 283 germline mutations and functional data on 426 mutant proteins.
All datasets can now be searched through SRS, a search system that allows to perform multiple user-defined queries and data retrieval in table or html formats.

 July 2004:

The database has been updated with data reported in publications edited in PubMed between March 2003 and December 2003. This R9 release contains 19,809 somatic mutations, 264 germline mutations and functional data on 423 mutant proteins.
A tool has been developed to search and display data and annotations on the functional properties of mutants.
A tool has been developed to visualized the 3D structure of the DNA-binding domain of p53 and color specific codons.
A list of cell-lines for which the TP53 gene status is known can be downloaded as a tab-delimited text file.
The different datasets previously maintained separately in different MS Access databases have been integrated in one single relational database maintained in MS SQL server centered on the the gene variation module, allowing a better consistency in the description of mutations across datasets.
Duplicates/errors have been identified and removed from the somatic dataset (40 mutations).

 June 2003:

The database has been updated with data reported in publications edited in PubMed between July 2002 and February 2003. This R8 release contains 18,585 somatic mutations, 225 germline mutations and functional data on 206 mutant proteins.
A new dataset has been created that provide annotations on the functional impact of mutations. It includes p53 mutants that have been tested in functional assays in yeast or human cells. This dataset can be downloaded as a tab-delimited text file.
Duplicates/errors have been identified and removed from the somatic dataset (28 mutations).

 September 2002:

The database has been updated with data reported in publications edited in PubMed between July 2001 and June 2002. This R7 release contains 17,689 somatic mutations and 225 germline mutations.
A new dataset has been created that provides information on the prognostic value of TP53 gene mutations. It includes a list of studies that have investigated the prognostic value of TP53 gene mutation status in specific cancers. Study design and main findings are indicated. This dataset can be downloaded as a tab-delimited text file.
The dataset on the prevalence of TP53 gene mutations has been extended and made available as an Access file.
Duplicates/errors have been identified and removed from the somatic dataset (73 mutations).

 January 2002:

The database has been updated with data reported in publications edited in PubMed between January 2001 and June 2001. This R6 release contains 16,285 somatic mutations, 213 germline mutations.
New annotations have been added to search individuals by population group, and mutations by genomic nucleotide position.
Duplicates have been identified and removed from the somatic dataset (385 mutations). Constant efforts are made to check for errors and track these duplicates. Despite these efforts, some may remain in the database and their identification is an ongoing task.

 June 2001:

The database has been updated with data reported in publications edited in PubMed between May and December 2000. This R5 release contains 15,121 somatic mutations and 196 germline mutations.
A web application has been created to search and analyze the dataset of somatic mutations.
A new dataset has been created that provides data on the prevalence of TP53 gene mutations. Tumor site and sample numbers are indicated. This dataset can be downloaded as a tab-delimited text file.
A slide-show on TP53 mutations in human cancer is freely available as a downloadable ppt file.
Duplicates have been identified and removed from the somatic dataset (388 mutations). Constant efforts are made to check for errors and track these duplicates. Despite these efforts, some may remain in the database and their identification is an ongoing task.

 July 2000:

The database has been updated with data reported in publications edited in PubMed between January 1998 and April 2000. This R4 release contains 14,000 somatic mutations and 144 germline mutations.
The datasets of somatic and germline mutations can be downloaded as tab-delimited text files.
A new database has been created in MS Access with a relational scheme to maintain data on germline TP53 mutations and Li-Fraumeni and Li-Fraumeni-Like syndromes.