Download the complete list of the p53 responsive-elements used in the functional assays reported in the database here (tab-delimited text to open in Excel or other software).
Additional p53 target genes are listed on the "p53 Knowledgebase" website.
Check also this interesting paper:
Gowrisankar S, Jegga AG. Regression based predictor for p53 transactivation. BMC Bioinformatics 2009 Jul 14;10:215.PubMed
| p53-RE name | Gene/Protein activity | Tetrameric p53-RE sequence (5’→3’)(a)(b) | p53-RE location | PubMed |
|---|---|---|---|---|
| RRRCWWGYYY
(N) RRRCWWGYYY R=A or G; W =A or T; Y = C or T; N= 0 to 13 nt |
||||
| p53CON | GGGCATGTCC GGGCATGTCC | 12909720 | ||
| GGGCTAGTCC GGGCTAGTCC | 12909720 | |||
| GGGCAAGTCT GGGCAAGTCT | 12909720 | |||
| GGACATGCCC GGGCATGTCC | 1588974 | |||
| PG13 | 13 copies of p53CON | 1588974 | ||
| 14-3-3s | Cell cycle arrest | AGGCATGTgC cAcCATGCCC | 2,5 kb | 9659898 |
| GtAGCAttAGCCC AGACATGTCC | 1,8 kb | 9659898 | ||
| AIP1 | Apoptosis | tctCTTGCCC GGGCTTGTCg | intron 1 | 11030628 |
| BAX | Apoptosis | tcACAAGTTaGAGACAAGCCT | -113 to -93 | 10559267 |
| AGACAAGCCT GGGCgTGggC | -102 to -83 | 10559267 | ||
| AGACAAGCCTGGGCGTGGGCTAtaTT | -102 to -77 | 10559267 | ||
| BTG2 | Cell cycle arrest | AGtCcgGgCAGAGcCcgagCa | -122 to -74 | 11814693 |
| CD95-Fas | Apoptosis | GGACAAGCCC tGACAAGCCa | intron 1 | 9841917 |
| C-FOS | Component
of AP-1 |
GGACTTGTCT GAGCgcGTgC AcACTTGTCa tAGtAAGaCT | intron 1 | 10082525 |
| CSR | Oxydative stress | GGGCAAGCCC AGACAAGTTg | intron 2 | 9580669 |
| CyclinG | Cell cycle progression | GcACAAGCCC AGGCTAGTCC | intron 1 | 8954786 |
| GADD45 | Cell cycle arrest | GAACATGTCT AAGCATGCTg | intron 3 | 8226988 |
| GML | Unknown | AtGCTTGCCC AGGCATGTCC AGGCATGTCC AGGCTgGTCC | -19 kb | 8934543 9169150 |
| EGFR | Cell proliferation | GAGCTAGaCgTCCGGGCAgcCCC | -265
to -239 |
8887630 |
| IGF-BP3-boxA | Apoptosis | AAACAAGCCaCcAACATGCTT | intron 1 | 7566179 |
| IGF-BP3-boxB | GGGCAAGaCC tGcCAAGCCT | intron 2 | 7566179 | |
| KILLER/DR5 | Apoptosis | GGGCATGTCC GGGCAAGaCg | intron 1 | 10777207 |
| MDM2 | p53 regulation | GGtCAAGTTC AGACAcGTCC | intron 1 | 7651818 |
| AGttAAGTCC tGACTTGTCT | intron 1 | 7651818 | ||
| MSH2 | DNA repair | AGGCTAGTTT(13bp)AAGtTTcCTT | -447 to -414 |
10984493 |
| NOXA | Apoptosis | AGGCTTGCCC cGGCAAGTTg | -174
to -155 |
10807576 |
| P53DINP1 | Regulation of p53-dependent apoptosis | GAACTTGggg GAACATGTTT | intron 2 | 11511362 |
| P53R2 | DNA repair | tGACATGCCC AGGCATGTCT | intron 1 | 10716435 |
| P53RFP | p21WAF1 regulation | AGACAgGTCC tGACAAGCag | -157 to -137 |
12853982 |
| PA26 | Oxydative metabolism | GGACAAGTCT ccACAAGTTC | intron 2 | 9926927 |
| PCNA | DNA repair / Replication | GAACAAGTCC GGGCATaTgT | -236
to -217 |
8570655 |
| PIDD | Apoptosis | AGGCcTGCCTGCGTGCTGGGACATGTCT | -54 to -26 | 10973264 |
| PIG3 | Apoptosis | cAGCTTGCCC AccCATGCTC | -328
to -308 |
9305847 |
| PIR121 | Apoptosis | GtACcTGTCCCTCTCAGTGcttCcTGCCa | -4061 to -3941 |
17245118 |
| PTEN | Cell cycle arrest | GAGCAAGCCCCAGGCAGCTACACTGGGCATGCTC | -1190
to -1157 |
11545734 |
| PTGF-beta_FBS01 | Growth inhibition | cAtCTTGCCC AGACTTGTCT | -898
to -879 |
10618379 |
| PTGF-beta_SBS01 | AGcCATGCCC GGGCAAGaaC | -43 to -24 | 10618379 | |
| PUMA | Apoptosis | ctcCTTGCCTTGGGCTAGgCC | -230 | 11463391 |
| ctGCAAGTCC tGACTTGTCC | -144 | 11463391 | ||
| RGC | Ribosomes synthesis | GGACTTGCCT GGcCTTGCCT | NA | 2047879 |
| RPS27L | Apoptosis | GGGCATGTag tGACTTGCCC | intron 1 | 17057733 |
| S100A2 | Calcium-binding protein | GGGCATGTgT GGGCAcGTTC | -3811 | 10094469 |
| SEMA3F | Angiogenesis inhibition | GGtCAAGTTCTTGAGCAAAcTCATGCTT | intron 1 | 17308083 |
| cAGCATGCCaTGAGGGgTAGggT | intron 1 | 17308083 | ||
| type IV collagenase | Angiogenesis | AGACAAGCCT GAACTTGTCT | -1649
to -1630 |
9343394 |
| WAF15’ | Cell cycle arrest | GAACATGTCC cAACATGTTg | -2.3 kb | 8242752 |
| WAF1 3’ | GAAgAAGaCT GGGCATGTCT | -1.4 kb | 9679054 |
(a) Non-functional putative p53-RE are indicated in italic.
(b) Bases that do not correspond to the p53-RE consensus sequence are in lowercase.