Structure Analysis

Structural properties of p53 and p53 mutants

This page provides a tool to visualize the position of mutations in the 3D structure of the DNA-binding domain of p53 protein. Links to structures of engeniered mutants are also provided.

3D Viewer
View structural motifs of p53 DNA-binding domain in contact with DNA*:
color residues (96 to 289) with options bellow (you may select several residues separated by a comma)

 Color:              Residue Number:
   
   
   
   
   
   

* You need to download and install CHIME plug-in (unzip with the free software ZipGenius) to use this option.

Download structures and tools
    
Structural impacts of mutations
View residues that are affected by a specific amino-acid substitution in the DNA-binding domain of p53. Principle and methods are available here.

Select mutant (ex. R248W):
  (AA/codons sequence)