IARC TP53 DATABASE - Database statistics

Database Statistics

R14, November 2009

The current version of the database is R14, released in November 2009.

The R14 release contains 26597 somatic mutations, 535 germline mutations, functional data on 2314 mutant proteins and TP53 gene status of 1993 cell-lines.

Here are some statistics on the database contents:

Somatic mutations ⁽¹⁾

Publication trends

Tumor site distribution of mutations

TP53 mutation prevalence

Type of mutations

Codon distribution of mutations

Prognostic value of somatic mutations

Cell-lines (included in dataset of somatic mutations)

Tumor site distribution

Type of mutations

Codon distribution of mutations

Germline mutations ⁽²⁾

Publication trends

Type of mutations

Codon distribution

Tumors associated with TP53 germline mutations

Prevalence of TP53 germline mutations in selected cohorts

Functional properties

Dataset contents

⁽¹⁾ Statistics on previous releases of the somatic dataset:

Database version	Release date	Mutations count	References count	Last Ref_ID	Added references	Added mutations	Deleted mutations*	PubMed search**
R3	-	10411	1048	1075	-	-	-	-
R4	July 2000	14050	1320	1369	294	3798	159	Jan 1998 to Apr 2000
R5	June 2001	15121	1412	1480	111	1459	388	May to Dec 2000
R6	Jan 2002	16285	1485	1571	91	1549	385	Jan to June 2001
R7	Sept 2002	17689	1599	1715	144	1477	73	July 2001 to June 2002
R8	June 2003	18585	1680	1810	95	924	28	July 2002 to Feb 2003
R9	July 2004	19809	1769	1921	111	1196	40	March to Dec 2003
R10	July 2005	21587	1876	2055	107	1788	10	Jan to Dec 2004
R11	Nov 2006	23544	1995	2221	120	2014	57	Jan to Dec 2005
R12	Nov 2007	24810	2081	2349	86	1331	65	Jan to Dec 2006
R13***	Nov 2008	24806	2081	2349	-	-	4	-
R14	Nov 2009	26597	2179	2483	98	1814	-	Jan to Dec 2007

* Data may be deleted if (1) they correspond to duplicate entries or (2) errors. Publication of the same set of samples in different papers by the same authors is a serious problem that has led to duplicates entries in the database in the past. We now perform systematic searches of the database under the author’s name to identify earlier entries that may correspond to the same dataset. We have also extensively reviewed the entire dataset in order to find and eliminate these duplicates. However, despite these efforts, some duplicates may remain in the database and their identification is an ongoing task.

** Papers edited in PubMed at the indicated dates were searched with selected keywords and reviewed to extract relevant data.

*** The dataset of somatic mutations has not been updated.

⁽²⁾ Statistics on previous releases of the germline dataset:

Database version	Release date	Mutations count	References count	Last Ref_ID	PubMed search**
R4	July 2000	144	71	74	Jan 1998 to Apr 2000
R5	June 2001	195	84	91	May to Dec 2000
R6	Jan 2002	213	90	99	Jan to June 2001
R7	Sept 2002	225	97	106	July 2001 to June 2002
R8	June 2003	225	98	108	-
R9	July 2004	264	112	125	July 2002 to Dec 2003
R10	July 2005	283	123	137	Jan to Dec 2004
R11	Nov 2006	376	142	156	Jan to Dec 2005
R12	Nov 2007	399	159	173	Jan 2006 to June 2007
R13	Nov 2008	423	164	181	Jul 2007 to July 2008
R14	Nov 2009	535	196	211	Aug 2008 to Aug 2009

** Papers edited in PubMed at the indicated dates were searched with selected keywords and reviewed to extract relevant data.