The dataset of somatic mutations contains TP53 somatic mutations that have been identified by sequencing and published in the peer-reviewed literature. This includes mutations reported in human tumor samples as well as in human cell-lines.

Three types of information are available:

Mutation type (1)	Mutation prevalence	Mutation and prognosis
Download data  Download Reference  Description	Download  R249S mutation in HCC **  Description	Download table format  MS Access Format  Description

** A new set of data is available, the TP53_R249S dataset, that contains the prevalence of the c.747G>T (p.R249S) mutation in liver cancers. It includes studies that have screened exon 7 of TP53 by sequencing as well as studies that have searched for this specific mutation by RFLP. The presence of this mutation in hepatocellular carcinomas has been linked to exposure to aflatoxins and HBV, and may thus constitutes a biomarker of exposure.

⁽¹⁾ Statistics on previous releases:

Database version	Release date	Mutations count	Ref. count	Last Ref_ID	Added ref.	Added mutations	Deleted mutations*	PubMed search**
R3	-	10411	1048	1075	-	-	-	-
R4	July 2000	14050	1320	1369	294	3798	159	Jan 1998 - Apr 2000
R5	June 2001	15121	1412	1480	111	1459	388	May - Dec 2000
R6	Jan 2002	16285	1485	1571	91	1549	385	Jan - June 2001
R7	Sept 2002	17689	1599	1715	144	1477	73	July 2001 - June 2002
R8	June 2003	18585	1680	1810	95	924	28	July 2002 - Feb 2003
R9	July 2004	19809	1769	1921	111	1196	40	March - Dec 2003
R10	July 2005	21587	1876	2055	107	1788	10	Jan - Dec 2004
R11	Nov 2006	23544	1995	2221	120	2014	57	Jan - Dec 2005
R12	Nov 2007	24810	2081	2349	86	1331	65	Jan - Dec 2006
R13***	Nov 2008	24806	2081	2349	-	-	4	-
R14	Nov 2009	26597	2179	2483	98	1814	-	Jan - Dec 2007
R15****	Nov 2010	27580	2218	2564	48	1021	38	2008 - 2009****

* Data may be deleted if (1) they correspond to duplicate entries or (2) errors. Publication of the same set of samples in different papers by the same authors is a serious problem that has led to duplicates entries in the database in the past. We now perform systematic searches of the database under the author’s name to identify earlier entries that may correspond to the same dataset. We have also extensively reviewed the entire dataset in order to find and eliminate these duplicates. However, despite these efforts, some duplicates may remain in the database and their identification is an ongoing task.
** Papers edited in PubMed at the indicated dates were searched with selected keywords and reviewed to extract relevant data.
*** The dataset of somatic mutations has not been updated.
**** The update only include a selection of papers (see database developments).