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Dataset of Somatic Mutations

The dataset of somatic mutations contains TP53 somatic mutations that have been identified by sequencing and published in the peer- reviewed literature. This includes mutations reported in human tumor samples as well as in human cell-lines.

Three types of information are available:

 Mutation type (1)  Mutation prevalence  Mutation and prognosis

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(1) Statistics on previous releases:

 Database version  Release date  Mutations count  References count  Last Ref_ID  Added references  Added mutations  Deleted mutations*  PubMed search**
R3 - 10411 1048 1075 - - - -
R4 July
2000
14050 1320 1369 294 3798 159 Jan 1998 to Apr 2000
R5 June
2001
15121 1412 1480 111 1459 388 May to Dec 2000
R6 Jan
2002
16285 1485 1571 91 1549 385 Jan to June 2001
R7 Sept
2002
17689 1599 1715 144 1477 73 July 2001 to June 2002
R8 June
2003
18585 1680 1810 95 924 28 July 2002 to Feb 2003
R9 July
2004
19809 1769 1921 111 1196 40 March to Dec 2003
R10 July
2005
21587 1876 2055 107 1788 10 Jan to Dec 2004
R11 Nov
2006
23544 1995 2221 120 2014 57 Jan to Dec 2005
R12 Nov
2007
24810 2081 2349 86 1331 65 Jan to Dec 2006
R13*** Nov
2008
24806 2081 2349 - - 4 -
R14 Nov
2009
26597 2179 2483 98 1814 - Jan to Dec 2007

* Data may be deleted if (1) they correspond to duplicate entries or (2) errors. Publication of the same set of samples in different papers by the same authors is a serious problem that has led to duplicates entries in the database in the past. We now perform systematic searches of the database under the author’s name to identify earlier entries that may correspond to the same dataset. We have also extensively reviewed the entire dataset in order to find and eliminate these duplicates. However, despite these efforts, some duplicates may remain in the database and their identification is an ongoing task.

** Papers edited in PubMed at the indicated dates were searched with selected keywords and reviewed to extract relevant data.

*** This dataset has not been updated with data published in 2007.