Gene Name p53-RE IARC TP53 database name Location Activity OMIM Tetrameric p53-response element sequence (5'3') p53-RE location Nb of non-consensus bases PubMed Ref Remarks RRRCWWGYYY(N)RRRCWWGYYY "R=A or G; W =A or T; Y = C or T; N= 0 to 13 nt" CON-A p53CON GGGCATGTCC GGGCATGTCC 0 12909720 CON-B GGGCTAGTCC GGGCTAGTCC 0 12909720 CON-C GGGCAAGTCT GGGCAAGTCT 0 12909720 p53CON GGACATGCCC GGGCATGTCC 0 1588974 p53CON AGGCATGTCT AGGCATGTCT 0 8816797 PG13 PG13 13 copies of p53CON 0 1589764 14.3.3sigma BDS-1 14-3-3s 1p35 Cell cycle arrest *601290 AGGCATGTgC cAcCATGCCC ­ 2,5 kb 3 9659898 BDS-1 is a non-functional putative p53RE BDS-2 GtAGCAttAGCCC AGACATGTCC ­ 1,8 kb 3 9659898 APAF1 p53BS1 APAF1 12q23 Apoptosis *602233 AGACATGTCTGGAGACCCTAGGAcGACAAGCCC -604 to -570 1 "11559530 11591730" p53BS2 AGGCAcGTCCCCAGCGAcAGCAgGCTC -765 to -739 3 "11389439 11591730" BAI1 BAI1 8q24 Angiogenesis inhibition *602682 NA intron 9 NA 9393972 BAX BAX-A BAX 19q13.3-13.4 Apoptosis *600040 tcACAAGTTaGAGACAAGCCT ­113 to -93 3 10559267 BAX-A and -C are two non-functional putative p53-RE BAX-B AGACAAGCCT GGGCgTGggC ­102 to -83 3 10559267 BAX-A and -B are two overlapping RE BAX-C AGACAAGCCTGGGCGTGGGCTAtaTT ­102 to -77 2 10559267 BTG2/TIS21/PC3 BS4 BTG2 1q32 Cell cycle arrest *601597 "CTGAAAAACGCTGCCCGGGGAA AGtCcgGgCaGAGcCcgagCa" -122 to -74 "/ 11" 11814693 These two p53-RE are adjacent CD95/FAS/APO-1 CD95-Fas 10q24.1 Apoptosis *134637 GGACAAGCCC tGACAAGCCa intron 1 2 9841917 C-FOS C-FOS 14q24.3 Component of AP-1 *164810 "GGACTTGTCT GAGCgcGTgC AcACTTGTCa tAGtAAGaCT" intron 1 "3 5" 10082525 These two p53-RE are adjacent CSR CSR 8p21 Oxydative stress *602728 GGGCAAGCCC AGACAAGTTg intron 2 1 9580669 CyclinG CyclinG 5q32-q34 Cell cycle progression *601578 GcACAAGCCC AGGCTAGTCC intron 1 1 8954786 GADD45 GADD45 1p34-p12 Cell cycle arrest *126335 GAACATGTCT AAGCATGCTg intron 3 1 8226988 GML GML 8q24.3 Unknown *602370 AtGCTTGCCC AGGCATGTCC -19 kb 1 "8934543 9169150" These two p53-RE are adjacent AGGCATGTCC AGGCTgGTCC 1 EGFR EGFR 7p12.3-12.1 Cell proliferation *131550 GAGCTAGaCgTCCGGGCAgcCCC -265 to -239 4 8887630 HGFIN HGFIN 7 Cell cycle regulation? NA 8 putative p53-Res -2135 to -1 NA 15684612 The functional p53-RE(s) has (have) not been identified yet HUNTINGTIN RE1 HUNTINGTIN 4p16.3 Involved in Huntington Disease 143100 cGcCATGTTgGCCAGGCTgGTCT -1855 to -1832 4 16278683 RE2 AtGCTTGTTCTACAGAAGAGCATGTTa intron 2 2 16278683 RE3 GGGCcTGCTTCCAGTTAAGCTTGCTT intron 3 1 16278683 IGF-BP3 box A IGF-BP3-boxA 7p14-p12 Apoptosis *146732 AAACAAGCCaCcAACATGCTT intron 1 2 7566179 box B IGF-BP3-boxB GGGCAAGaCC tGcCAAGCCT intron 2 3 7566179 KAI1/CD82 KAI1 11p11.2 Metastasis inhibition *600623 AGGCAAGCTgGGGCAGctCAAGCCT -882 to-858 3 9736732 KILLER/DR5 KILLER/DR5 8p22.p21 Apoptosis *603612 GGGCATGTCC GGGCAAGaCg intron 1 2 10777207 MASPIN/SERPINB5 MBS1 MASPIN 18q21.3 Angiogenesis inhibition *154790 GAACATGTTgGAGGCcTtTTg -297 to +87 4 10692390 MBS2 is a non-functional putative p53-RE MBS2 GGACAAGCTgCCAAGAGGCTTGagT -297 to +87 3 10692390 human MDM2-P2 MDM2-RE1 MDM2 12q14.3-q15 p53 regulation *164785 GGtCAAGTTC AGACAcGTCC intron 1 2 7651818 These two p53-RE are separated by the following 17bp: CGAAACTGCAGTAAAAGG MDM2-RE2 AGttAAGTCC tGACTTGTCT intron 1 3 7651818 MDM2-RE2 is a non-functional putative p53-RE MSH2 MSH2 2p22-p21 DNA mismatch repair *609309 AGGCTAGTTT(13bp)AAGtTTcCTT -447 to -414 2 10984493 Regulation c-Jun-dependent in response to UV treatment murine NOXA NOXA 18 Apoptosis *604959 AGGCTTGCCC cGGCAAGTTg -174 to -155 2 10807576 p53AIP1 AIP1 11q24 Apoptosis *605426 tctCTTGCCC GGGCTTGTCg intron 1 4 11030628 P53DINP1 P53DINP1 8q22 Regulation of p53-dependent apoptosis *606185 GAACTTGggg GAACATGTTT intron 2 3 11511362 P53R2 P53R2 8q23.1 DNA repair *604712 tGACATGCCC AGGCATGTCT intron 1 1 10716435 P53RDL1/UNC5B p53BS-A P53RDL1 10q22.1 Apoptosis *607870 NA intron 1 3 12598906 p53BS-B NA intron 1 4 12598906 p53BS-C is a non-functional putative p53-RE p53BS-C NA intron 1 4 12598906 P53RFP p53BS1 P53RFP 6p p21WAF1 regulation NA AGACAgGTCC tGACAAGCag -157 to -137 4 12853982 PA26/SESTRIN 1 PA26 6q21 Oxydative metabolism *606103 GGACAAGTCT ccACAAGTTC intron 2 2 9926927 PAI-1 PAI-1 7q21.3-q22 Cell migration *173360 AcACATGCCT cAGCAAGTCC -159 to -134 2 7479001 PCNA PCNA 20p12 DNA repair, replication *176740 GAACAAGTCC GGGCATaTgT ­236 to -217 2 8570655 PIDD PIDD 11 Apoptosis *605247 AGGCcTGCCTGCGTGCTGGGACATGTCT -54 to -26 1 10973264 PIG3 PIG3 2p Apoptosis *605171 cAGCTTGCCC AccCATGCTC ­328 to -308 3 9305847 PIR121/CYFIP2 PIR121 5q33.3 Apoptosis *606323 GtACcTGTCCCTCTCAGTGcttCcTGCCa -4061 to -3941 7 17245118 PTEN PTEN 10q23,31 Cell cycle arrest *601728 GAGCAAGCCCCAGGCAGCTACACTGGGCATGCTC ­1190 to -1157 0 11545734 PTGF-beta/GDF15 FBS01 PTGF-beta_FBS01 19p13.2-p13.1 Growth inhibition *605312 cAtCTTGCCC AGACTTGTCT -898 to -879 2 10618379 SBS01 PTGF-beta_SBS01 AGcCATGCCC GGGCAAGaaC -43 to -24 3 10618379 PUMA BS1 PUMA 19q Apoptosis *605854 ctcCTTGCCTTGGGCTAGgCC -230 4 11463391 BS1 is a non-functional putative p53-RE BS2 ctGCAAGTCC tGACTTGTCC -144 3 11463391 RGC RGC NA Ribosomes synthesis NA GGACTTGCCT GGcCTTGCCT NA 1 2047879 RPS27L RPS27L 15q22.2 Apoptosis NA GGGCATGTag tGACTTGCCC intron 1 3 17057733 S100A2 S100A2 1q21 Calcium-binding protein *176993 GGGCATGTgT GGGCAcGTTC -3811 2 10094469 SEMA3F BS1 SEMA3F 3p21.3 Angiogenesis inhibition *601124 GGtCAAGTTCTTGAGCAAActCATGCTT intron 1 3 17308083 BS2 cAGCATGCCaTGAGGGgTAGggT intron 1 5 17308083 BS2 is a non-functional putative p53-RE Murine SLUG/SNAI2 RE1 SLUG 8q11 "Neural developement Regulation of p53-dependent apoptosis" *602150 NA intron 1 NA 16286009 So far, only p53-RE in the murine gene have been functionally identified. p53-RE in human SLUG have not yet been studied. RE2 NA intron 2 NA 16286009 TYPE IV COLLAGENASE type IV collagenase 16q13 Angiogenesis *120360 AGACAAGCCT GAACTTGTCT -1649 to -1630 0 9343394 WAF1 5' WAF1 WAF1 5' 6p21.2 Cell cycle arrest *116899 GAACATGTCC cAACATGTTg ­ 2,3 kb 2 8242752 3' WAF1 3' GAAgAAGaCT GGGCATGTCT ­ 1,4 kb 2 9679054 WTH3 WTH3 2q21.1 Apoptosis NA NA -396 to -289 5 17426708