The IARC TP53 Mutation Database compiles all TP53 gene variations identified in human populations and tumor samples. Data are compiled from the peer-reviewed literature and from generalist databases.

The following datasets are available:

TP53 somatic mutations in sporadic cancers

TP53 germline mutation in familial cancers

Common TP53 polymorphisms identified in human populations

Functional and structural properties of P53 mutant proteins

TP53 gene status in human cell-lines

Mouse-models with engineered TP53

The database includes various annotations on the predicted or experimentally assessed functional impact of mutations, clinicopathologic characteristics of tumors and demographic and life-style information on patients.

The database is meant to be a source of information on TP53 mutations for a broad range of scientists and clinicians who work in different research areas:

Basic research, to study the structural and functional aspects of the p53 protein

Molecular pathology of cancer, to understand the clinical significance of mutations identified in cancer patients

Molecular epidemiology of cancer, to analyze the links between specific exposures and mutation patterns and to make inferences about possible causes of cancer

Molecular genetics, to analyze genotype/phenotype relationships

See detailed information on database contents in the user's guide.